CBD vs. THC: What's the Difference and How Do They Work? -
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Cannabidiol (CBD) and tetrahydrocannabinol (THC) are two of the most well-known and studied compounds found in cannabis. However, many people are still unsure about their differences and how they affect the body. 


In this blog, we will delve into the characteristics of CBD and THC, how they work, their effects on the body, and their differences. Whether you’re a seasoned cannabis user or a curious newbie, keep reading to learn more about CBD and THC!


Definition of CBD and THC


CBD and THC are naturally occurring compounds in the Cannabis sativa plant. They belong to a group of chemical compounds called cannabinoids, which interact with the human body’s endocannabinoid system to regulate various physiological processes.


Cannabidiol (CBD) is a non-psychoactive compound that does not induce the “high” typically associated with cannabis use. It is known for its potential therapeutic benefits, including anti-inflammatory, anti-anxiety, and neuroprotective properties.


On the other hand, tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis, responsible for the mind-altering effects, or “high,” experienced by users.

While THC has also been found to possess potential medicinal properties, such as pain relief and appetite stimulation, its psychoactive nature has made it more controversial.


Popularity and Availability of CBD and THC Products


In recent years, CBD and THC products have seen a dramatic rise in popularity, driven by a growing awareness of their potential health benefits and an increasing number of countries and states legalizing or decriminalizing cannabis for medical or recreational use.

This has led to an explosion in the availability of various CBD and THC-infused products, ranging from oils, tinctures, and edibles to topical creams, vape cartridges, and even pet products.


Due to their non-psychoactive nature, CBD products have gained wider acceptance and can be found in health stores, pharmacies, and online retailers.

Many people turn to CBD for its potential to alleviate physical discomfort, anxiety, and sleep issues without the intoxicating effects of THC.


THC products, while more regulated, are becoming increasingly accessible in regions where cannabis has been legalized for recreational or medical use.

These products cater to individuals seeking the psychoactive effects of THC or those who find the compound beneficial for their specific medical condition.


The Chemistry of CBD and THC


Cannabidiol (CBD) and tetrahydrocannabinol (THC) are two naturally occurring compounds in the cannabis plant. While they share many similarities, their chemical structures and interactions with the human body set them apart.


Structural Differences between CBD and THC


CBD and THC have a similar chemical formula at the molecular level, with 21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms (C21H30O2). However, their structures differ due to the arrangement of a single atom.

In THC, the cyclic ring contains a double bond; in CBD, this bond is shifted, creating a hydroxyl group. This seemingly minor molecular structure difference significantly impacts how each compound interacts with the endocannabinoid system.


Interaction with the Endocannabinoid System


The endocannabinoid system (ECS) is a complex cell-signaling system found in the human body.

Playing a crucial role in regulating various physiological processes, such as mood, appetite, pain sensation, and immune response. The ECS is composed of three main components:


  • Endocannabinoids (naturally occurring compounds in the body)
  • Receptors (CB1 and CB2)
  • Enzymes responsible for breaking down endocannabinoids


CBD and THC interact differently with the CB1 and CB2 receptors in the ECS.

THC has a high affinity for the CB1 receptor, mainly located in the brain, leading to its psychoactive effects. When THC binds with the CB1 receptor, it triggers dopamine release, resulting in the “high” commonly associated with marijuana use.


On the other hand, CBD has a low affinity for CB1 receptors and acts as an antagonist. Instead of directly binding to the receptors.

CBD influences the ECS indirectly by preventing endocannabinoid breakdown or modulating other receptors’ activity. This lack of direct binding is why CBD does not produce the psychoactive effects of THC.


CBD has a higher affinity for CB2 receptors, predominantly found in the immune system and peripheral tissues. By interacting with these receptors, CBD may help alleviate inflammation, pain, and other immune-related conditions.


The Effects of CBD and THC


Here are the psychoactive and non-psychoactive effects of these two cannabinoids:


The Psychoactive Effects of THC


Some of the common psychoactive effects of THC include:


  • Euphoria and relaxation
  • Heightened sensory perception
  • Altered perception of time
  • Increased appetite
  • Short-term memory impairment


The Non-Psychoactive Effects of CBD


CBD has been praised for its potential therapeutic benefits, which include:


Anti-iInflammatory Properties:

CBD may help reduce inflammation, proving beneficial for arthritis and inflammatory bowel disease.

Anxiolytic Effects:

Studies suggest that CBD may help alleviate anxiety by influencing serotonin receptors and regulating the stress response.

Neuroprotective Properties:

CBD has shown the potential to protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s by reducing oxidative stress and inflammation in the brain.

Pain Relief:

CBD’s interaction with the body’s endocannabinoid system may help reduce pain and manage chronic conditions such as fibromyalgia and neuropathic pain.


Medical Benefits of CBD and THC


The conditions that can be treated with CBD:


  1. Epilepsy: CBD has been shown to be an effective treatment for certain types of epilepsy, such as Dravet syndrome and Lennox-Gastaut syndrome. In fact, the FDA has approved a CBD-based drug called Epidiolex for these conditions.


  1. Anxiety: Several studies have found that CBD may help reduce anxiety, making it a potential option for individuals suffering from anxiety disorders like generalized anxiety disorder, social anxiety disorder, and panic disorder.


  1. Chronic Pain: CBD has anti-inflammatory properties that can help alleviate chronic pain, such as neuropathic pain, arthritis, and fibromyalgia.


  1. Insomnia: CBD may improve sleep by reducing anxiety and promoting relaxation, making it a possible treatment option for those with sleep disorders.


The conditions that can be treated with THC:


  1. Nausea and Vomiting: THC has been used to treat nausea and vomiting associated with chemotherapy, and it is an active ingredient in FDA-approved medications like Marinol and Cesamet.


  1. Appetite Stimulation: THC can help increase appetite in patients with conditions like cancer, HIV/AIDS, and other wasting syndromes.


  1. Muscle Spasticity: THC may help reduce muscle spasticity in patients with multiple sclerosis and other neurological conditions.


  1. Glaucoma: Some research suggests that THC can help lower intraocular pressure in patients with glaucoma, although more research is needed.


The Conditions that can benefit from both CBD and THC:


  1. Pain Management:

    Combining CBD and THC can provide synergistic effects in pain relief, as they may target different pain pathways in the body. This combination may be particularly helpful in managing neuropathic pain and cancer-related pain.


  1.  Multiple Sclerosis:

    Both CBD and THC have been shown to help with muscle spasticity and other symptoms related to multiple sclerosis.


  1. Inflammatory Bowel Disease:

    CBD and THC may help reduce inflammation and alleviate symptoms in patients with conditions like Crohn’s disease and ulcerative colitis.


  1. Parkinson’s Disease:

    Some studies suggest that CBD and THC may help alleviate symptoms such as tremors, rigidity, and bradykinesia in patients with Parkinson’s disease.


It’s essential to consult a healthcare professional before using CBD or THC to treat any medical condition.

As the appropriate dosage and administration method may vary depending on individual needs and medical history. Additionally, it’s crucial to consider the legal status of CBD and THC in your jurisdiction.


Legal Status of CBD and THC


Under federal law, CBD derived from cannabis is considered a Schedule 1 substance and is illegal, but CBD derived from a hemp source containing less than 0.3% THC by dry weight is legal. 


THC, on the other hand, is illegal under federal law. However, the 2018 Farm Bill legalized hemp by removing it from the list of controlled substances, which means that all hemp-derived products containing 0.3% delta-9 THC or less are legal.


State-level regulations on CBD and THC products vary. Some states have legalized medical and/or recreational use of marijuana and THC, while others have only legalized medical use. 


As for CBD, it is legal in some states for medical use only. While others have legalized it for both medical and recreational use. Some states still prohibit CBD use in any form.


How to Choose Between CBD and THC


Here are the factors to consider when choosing between CBD and THC, recommended dosages, and potential side effects and precautions to remember.


Desired Effects:

CBD is known for its non-psychoactive properties and is often used to treat anxiety, inflammation, and pain.

On the other hand, THC is psychoactive and is responsible for the “high” feeling associated with marijuana use. When choosing between the two, consider whether you seek a psychoactive effect.


Medical Conditions:

Some medical conditions may respond better to CBD or THC. For example, CBD may be more effective in treating epilepsy, while THC may be more suitable for managing chronic pain or insomnia.


Legal Status:

The legality of CBD and THC products varies by country, state, or region. Ensure that the product you choose is legal in your area.


Drug Testing:

If you are subject to drug testing, be aware that THC may show up on tests, while CBD typically will not.


Recommended Dosages for Different Types of CBD and THC Products:


CBD Products:


  • Oils and tinctures: 15-25 mg per day
  • Capsules: 10-50 mg per day
  • Topicals: Apply a small amount to the affected area as needed
  • Edibles: 5-25 mg per serving


THC Products:

  • Smoked or vaporized: Start with one or two puffs and assess your tolerance.
  • Edibles: Begin with 5 mg and wait at least 2 hours before consuming more.
  • Tinctures: Start with 1-2 drops under the tongue and increase gradually.


Always consult a healthcare professional before starting any new supplement or medication, especially if you have pre-existing health conditions or are taking other medications.


Potential Side Effects and Precautions to Keep in Mind:


CBD Side Effects:

CBD is generally well-tolerated, but some people may experience side effects such as dry mouth, dizziness, diarrhea, or changes in appetite or weight.


THC Side Effects:

Common side effects of THC include dry mouth, red eyes, increased heart rate, memory impairment, and coordination problems. More severe side effects can include anxiety, paranoia, and hallucinations.


Drug Interactions:

Both CBD and THC can interact with other medications, leading to increased side effects or reduced effectiveness. Talk to your healthcare provider before combining CBD or THC with other medications.


Pregnancy and Breastfeeding:

The use of CBD and THC during pregnancy and breastfeeding is not well-studied, and it is best to avoid their use during these times.


Always consult a healthcare professional before incorporating CBD or THC into your wellness routine.




In conclusion, CBD and THC are two compounds found in the cannabis plant that have distinct chemical structures. They both have interactions with the endocannabinoid system. Which leads to different potential therapeutic effects on the body.


While THC is the primary psychoactive compound in cannabis, CBD is non-psychoactive and is known for its potential therapeutic benefits.

Both compounds have gained popularity and accessibility in recent years, with many countries and states legalizing or decriminalizing cannabis for medical or recreational use.


If you’re looking for high-quality CBD products that contain a full range of beneficial cannabinoids and terpenes, consider True Spectrum. True Spectrum offers a wide range of CBD products made from organic.

Non-GMO hemp and extracted using CO2 to preserve the plant’s natural compounds. 


Their products undergo rigorous third-party testing to ensure purity, potency, and quality.

Whether you’re looking for CBD oil, capsules, gummies, or topicals. True Spectrum has something for you. So, if you want to experience CBD’s full potential, try True Spectrum!


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